37| Neuropsychology 3.0: Phenomics and Cognitive Ontologies – A Conversation With Dr. Bob Bilder

Robert “Bob” Bilder, Ph.D., ABPP-CN, returns to discuss another passion area of his, which is the study of phenomics and cognitive ontologies.  He discusses how these areas of study are integral to “Neuropsychology 3.0” and are key to our ability to pace medical technological advancements in pursuit of precision medicine.

A pdf of the transcript for this episode is available here.

Topics Covered (with time stamps)

Main Episode

  • Ryan and John define important terminology (00:53)
  • Bob defines genomics (6:33)
  • The utility of identifying the genetic underpinnings of psychological dysfunction (13:40)
  • Application of neuropsychological and genetic evaluations (14:37)
  • Validating neuropsychology tests to improve ecological and physiological validity (16:03)
  • Bob defines cognitive ontologies (17:20)
  • Benefits of discussing cognitive constructs rather than patterns or general scores (25:38)
  • Progress towards using neural circuits to understand neurobiological change (27:30)
  • Breadth vs. depth of knowledge in neuropsychological research (30:20)

Bonus Content

  • John and Ryan discuss the implications of improving neuropsychological construct definitions (34:40)
  • Domain impurity (39:55)

For Bob’s biography, please see our previous episode.

Selected References

Bilder, R. M. (2008). Phenomics: building scaffolds for biological hypotheses in the post-genomic era. Biological psychiatry63(5), 439.

Bilder, R. M., & Howe, A. G. (2013). Multilevel models from biology to psychology: mission impossible?. Journal of Abnormal Psychology122(3), 917.