In this episode we highlight topics such as the meaning and evolution of the term “eloquent cortex,” localized versus distributed models of brain functioning, aggressiveness versus conservatism of neurosurgeons during resections, the “onco-functional balance,” electrocorticography and stereo EEG procedures, the Wada procedure, the clinical and functional utility of brain mapping, the availability of brain mapping to people of lower SES, neuropsychologists’ role in educating patients and families, cognitive testing during the mapping procedure, and NeuroMapper.
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Guest disclosures: None.
About Dave
Dr. David Sabsevitz is a practicing neuropsychologist and associate professor at Mayo Clinic in Jacksonville, Florida. He has a primary appointment in the Department of Psychiatry and Psychology and a joint appointment in the Department of Neurosurgery. He is board certified by the American Board of Professional Psychology in clinical neuropsychology and specializes in the evaluation and treatment of adults with neurological, and neuropsychiatric disorders. His clinical interests involve onco-epilepsy with focus on the pre-surgical evaluation of brain tumor and epilepsy patients, functional brain mapping, and extra- and intraoperative brain mapping to assist surgical planning in these patient populations. He has numerous publications in peer reviewed scientific journals and is widely recognized for developing innovative brain mapping techniques for awake brain tumor and epilepsy surgery. Dr. Sabsevitz is also very involved in teaching and education and lectures regularly at both the regional and national level.
About Vigneswaran
Dr Vigneswaran Veeramuthu currently serves as a resident Consultant Clinical Neuropsychologist (Adult and Pediatrics) at Thomson Hospital Kota Damansara, Malaysia. He completed his doctoral training with a PhD in Clinical Neuropsychology (Neurosurgery) from University of Malaya in 2016, a clinical fellowship at Hawaii Pacific Neuroscience Institute (2013), and recently a clinical observation at the Department of Neurosurgery, University of California San Francisco (2023). His clinical and research interest lies predominantly in the area of neuropsychological evaluation, presurgical planning, intraoperative brain mapping, advance neuroimaging and rehabilitative interventions in neurological surgery (brain tumors and epilepsy predominantly) and disorders of consciousness.
References
Bohm, P., McKay, J., Lucas, J., Sabsevitz, D., Feyissa, A. M., Ritaccio, T., Grewal, S. S., Wharen, R. E., Gupta, V., & Tatum, W. O. (2020). Wada testing and fMRI in a polyglot evaluated for epilepsy surgery. Epileptic Disorders, 22(2), 207–213. https://doi.org/10.1684/epd.2020.1145
Bow, H., & Chen, J. W. (2021). Commentary: Three-Dimensionally Printed Surgical Simulation Tool for Brain Mapping Training and Preoperative Planning. Operative Neurosurgery, 22(2), e104–e105. https://doi.org/10.1227/ons.0000000000000063
Colaguori, F., Marin-Mera, M., McDonnell, M., Martínez, J., Valero-Moreno, F., Damon, A., Domingo, R. A., Clifton, W., Fox, W. C., Chaichana, K., Middlebrooks, E. H., Sabsevitz, D., Forry, R., & Quiñones-Hinojosa, A. (2021). Three-Dimensionally Printed Surgical Simulation Tool for Brain Mapping Training and Preoperative Planning. Operative Neurosurgery, 21(6), 523–532. https://doi.org/10.1093/ons/opab331
Domingo, R. A., Vivas-Buitrago, T., De Biase, G., Middlebrooks, E. H., Bechtle, P. S., Sabsevitz, D. S., Quiñones-Hinojosa, A., & Tatum, W. O. (2021). Intraoperative Seizure Detection During Active Resection of Glioblastoma Through a Novel Hollow Circular Electrocorticography Array. Operative Neurosurgery, 21(2), E147–E152. https://doi.org/10.1093/ons/opab110
Drane, D. L., Pedersen, N. P., Sabsevitz, D. S., Block, C., Dickey, A. S., Alwaki, A., & Kheder, A. (2021). Cognitive and Emotional Mapping With SEEG. Frontiers in Neurology, 12. https://doi.org/10.3389/fneur.2021.627981
Ekert, J. O., Sabsevitz, D. S., Del Campo, I. M., Goyal, A., Gillespie, C. S., Middlebrooks, E. H., Chaichana, K. L., Lee, K. S., Sanchez-Garavito, J. E., & Quiñones-Hinojosa, A. (2024). Awake brain mapping paradigms for nondominant hemisphere gliomas. Neurosurgical FOCUS, 56(2), E7. https://doi.org/10.3171/2023.11.focus23610
Freund, B. E., Feyissa, A. M., Khan, A., Middlebrooks, E. H., Grewal, S. S., Sabsevitz, D., Sherman, W. J., Quiñones-Hinojosa, A., & Tatum, W. O. (2023). Early Postoperative Seizures Following Awake Craniotomy and Functional Brain Mapping for Lesionectomy. World Neurosurgery, 181, e732–e742. https://doi.org/10.1016/j.wneu.2023.10.119
Freund, B. E., Feyissa, A. M., Khan, A., Sirven, J. I., Grewal, S. S., Sabsevitz, D., Moniz-Garcia, D., Quinones-Hinojosa, A., & Tatum, W. O. (2023). Enhanced sensitivity of electrocorticography during awake craniotomy using a novel circular grid electrode. Journal of Neuro-Oncology, 165(2), 313–320. https://doi.org/10.1007/s11060-023-04495-0
Hameed, N. U. F., Zhao, Z., Zhang, J., Bu, L., Zhou, Y., Jin, L., Bai, H., Li, W., Tang, J., Lu, J., Wu, J., & Mao, Y. (2021). A Novel Intraoperative Brain Mapping Integrated Task-Presentation Platform. Operative Neurosurgery, 20(5), 477–483. https://doi.org/10.1093/ons/opaa476
Koay, J. M., Michaelides, L., Moniz-Garcia, D. P., Quinones-Hinojosa, A., Chaichana, K., Almeida, J. P., Gruenbaum, B. F., Sherman, W. J., & Sabsevitz, D. S. (2024). Repeated surgical resections for management of high-grade glioma and its impact on quality of life. Journal of Neuro-Oncology, 167(2), 267–273. https://doi.org/10.1007/s11060-024-04600-x
Lakhani, D. A., Sabsevitz, D. S., Chaichana, K. L., Quiñones-Hinojosa, A., & Middlebrooks, E. H. (2023). Current State of Functional MRI in the Presurgical Planning of Brain Tumors. Radiology Imaging Cancer, 5(6). https://doi.org/10.1148/rycan.230078
Martín-Fernández, J., Gabarrós, A., & Fernandez-Coello, A. (2022). Intraoperative Brain Mapping in Multilingual Patients: What Do We Know and Where Are We Going? Brain Sciences, 12(5), 560. https://doi.org/10.3390/brainsci12050560
Middlebrooks, E. H., Gupta, V., Agarwal, A. K., Freund, B. E., Messina, S. A., Tatum, W. O., Sabsevitz, D. S., Feyissa, A. M., Mirsattari, S. M., Galan, F. N., Quinones-Hinojosa, A., Grewal, S. S., & Murray, J. V. (2024). Radiologic Classification of Hippocampal Sclerosis in Epilepsy. American Journal of Neuroradiology, ajnr.A8214. https://doi.org/10.3174/ajnr.a8214
Moniz-Garcia, D., Bojaxhi, E., Borah, B. J., Dholakia, R., Kim, H., Sousa-Pinto, B., Almeida, J. P., Mendhi, M., Freeman, W. D., Sherman, W., Christel, L., Rosenfeld, S., Grewal, S. S., Middlebrooks, E. H., Sabsevitz, D., Gruenbaum, B. F., Chaichana, K. L., & Quiñones-Hinojosa, A. (2024). Awake Craniotomy Program Implementation. JAMA Network Open, 7(1), e2352917. https://doi.org/10.1001/jamanetworkopen.2023.52917
Oelschlägel, M., Meyer, T., Morgenstern, U., Wahl, H., Gerber, J., Reiß, G., Koch, E., Steiner, G., Kirsch, M., Schackert, G., & Sobottka, S. B. (2020). Mapping of language and motor function during awake neurosurgery with intraoperative optical imaging. Neurosurgical FOCUS, 48(2), E3. https://doi.org/10.3171/2019.11.focus19759
Ortiz, K. J., Hawayek, M. I., Middlebrooks, E. H., Sabsevitz, D. S., Garcia, D. P., Quinones-Hinojosa, A., & Chaichana, K. L. (2020). Intraoperative Direct Stimulation Identification and Preservation of Critical White Matter Tracts During Brain Surgery. World Neurosurgery, 146, 64–74. https://doi.org/10.1016/j.wneu.2020.10.100
Prat-Acín, R., Galeano-Senabre, I., López-Ruiz, P., Ayuso-Sacido, A., & Espert-Tortajada, R. (2020). Intraoperative brain mapping of language, cognitive functions, and social cognition in awake surgery of low-grade gliomas located in the right non-dominant hemisphere. Clinical Neurology and Neurosurgery, 200, 106363. https://doi.org/10.1016/j.clineuro.2020.106363
Raghavan, M., Li, Z., Carlson, C., Anderson, C. T., Stout, J., Sabsevitz, D. S., Swanson, S. J., & Binder, J. R. (2017). MEG language lateralization in partial epilepsy using dSPM of auditory event-related fields. Epilepsy & Behavior, 73, 247–255. https://doi.org/10.1016/j.yebeh.2017.06.002
ReFaey, K., Tripathi, S., Bhargav, A. G., Grewal, S. S., Middlebrooks, E. H., Sabsevitz, D. S., Jentoft, M., Brunner, P., Wu, A., Tatum, W. O., Ritaccio, A., Chaichana, K. L., & Quinones-Hinojosa, A. (2020). Potential differences between monolingual and bilingual patients in approach and outcome after awake brain surgery. Journal of Neuro-Oncology, 148(3), 587–598. https://doi.org/10.1007/s11060-020-03554-0
Rigolo, L., Essayed, W. I., Tie, Y., Norton, I., Mukundan, S., & Golby, A. (2019). Intraoperative Use of Functional MRI for Surgical Decision Making after Limited or Infeasible Electrocortical Stimulation Mapping. Journal of Neuroimaging, 30(2), 184–191. https://doi.org/10.1111/jon.12683
Roland, J. L., Hacker, C. D., & Leuthardt, E. C. (2020). A Review of Passive Brain Mapping Techniques in Neurological Surgery. Neurosurgery, 88(1), 15–24. https://doi.org/10.1093/neuros/nyaa361
Rossi, M., Sciortino, T., Nibali, M. C., Gay, L., Viganò, L., Puglisi, G., Leonetti, A., Howells, H., Fornia, L., Cerri, G., Riva, M., & Bello, L. (2020). Clinical Pearls and Methods for Intraoperative Motor Mapping. Neurosurgery, 88(3), 457–467. https://doi.org/10.1093/neuros/nyaa359
Seidel, K., Szelényi, A., & Bello, L. (2022). Intraoperative mapping and monitoring during brain tumor surgeries. Handbook of Clinical Neurology, 133–149. https://doi.org/10.1016/b978-0-12-819826-1.00013-2
Soloukey, S., Vincent, A. J. P. E., Satoer, D. D., Mastik, F., Smits, M., Dirven, C. M. F., Strydis, C., Bosch, J. G., Van Der Steen, A. F. W., De Zeeuw, C. I., Koekkoek, S. K. E., & Kruizinga, P. (2020). Functional Ultrasound (fUS) During Awake Brain Surgery: The Clinical Potential of Intra-Operative Functional and Vascular Brain Mapping. Frontiers in Neuroscience, 13. https://doi.org/10.3389/fnins.2019.01384
Suarez-Meade, P., Marenco-Hillembrand, L., Prevatt, C., Murguia-Fuentes, R., Mohamed, A., Alsaeed, T., Lehrer, E. J., Brigham, T., Ruiz-Garcia, H., Sabsevitz, D., Middlebrooks, E. H., Bechtle, P. S., Quinones-Hinojosa, A., & Chaichana, K. L. (2020). Awake vs. asleep motor mapping for glioma resection: a systematic review and meta-analysis. Acta Neurochirurgica, 162(7), 1709–1720. https://doi.org/10.1007/s00701-020-04357-y
Suarez-Meade, P., Marenco-Hillembrand, L., Sabsevitz, D., Okromelidze, L., Perdikis, B. B., Sherman, W. J., Quinones-Hinojosa, A., Middlebrooks, E. H., & Chaichana, K. L. (2022). Surgical resection of gliomas in the dominant inferior frontal gyrus: Consecutive case series and anatomy review of Broca’s area. Clinical Neurology and Neurosurgery, 223, 107512. https://doi.org/10.1016/j.clineuro.2022.107512
